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目的：观察尼群地平（Ｎｉｔｒｅｎｄｉｐｉｎｅ）对大鼠早期肺缺血再灌注损伤的防治作用和可能的机制。方法：将７２只大鼠随机分为手术对照组（ＯＣ）、肺缺血再灌注损伤组（ＩＲ）和尼群地平处理组（ＮＴ），采用肺在体缺血再灌注模型，动态测定肺组织和血浆肿瘤坏死因子－α（ＴＮＦ－α）、白介素－６（ＩＬ－６）、白介素－８（ＩＬ－８）、肺组织总钙、肺组织干／湿重比值（Ｄ／Ｗ）和肺静态顺应性（Ｃｓｔ）变化。结果：肺缺血再灌注损伤早期肺组织总钙水平升高，肺组织ＴＮＦ－α、ＩＬ－６和ＩＬ－８相继释放增加并与肺Ｄ／Ｗ、肺Ｃｓｔ下降呈显著相关性。尼群地平处理后，肺组织总钙和ＴＮＦ－α、ＩＬ－６、ＩＬ－８水平显著降低（Ｐ＜０．０５和Ｐ＜０．０１），肺Ｄ／Ｗ升高，肺Ｃｓｔ改善。结论：尼群地平可通过阻滞钙通道，减少细胞钙内流，抑制炎性细胞因子释放，减轻肺缺血再灌注损伤。
Objective: To observe the preventive and therapeutic effects of Nitrendipine on early lung ischemia-reperfusion injury in rats and its possible mechanism. Methods: Seventy two rats were randomly divided into operation control group (OC), lung ischemia / reperfusion injury group (IR) and nitrendipine treatment group (NT). The model of lung ischemia / reperfusion was established. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), total lung calcium, Changes in static lung compliance (Cst). Results: The level of total calcium in lung tissue increased at the early stage of lung ischemia-reperfusion injury. The release of TNF-α, IL-6 and IL-8 in lung tissue increased successively and was significantly correlated with the decrease of D / W and Cst. After treatment with nitrendipine, the levels of total calcium, TNF-α, IL-6 and IL-8 in lung tissue were significantly decreased (P <0.05 and P <0.01), the lung D / W was increased and lung Cst was improved. Conclusion: Nitrendipine can reduce the calcium influx, decrease the intracellular calcium influx, inhibit the release of inflammatory cytokines and reduce the lung ischemia-reperfusion injury.