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目的探讨白细胞介素-6(IL-6)在肺结核病人引起反应性血小板增多和急性时相反应的作用。方法根据血小板计数,将72例肺结核病人分为两组,血小板计数正常组37例,血小板计数增多组35例,同时设正常对照组31例。分别测定血清IL-6、C反应蛋白(CRP)、白蛋白(ALB)。结果血小板正常组IL-6浓度为(38±54)pg/ml,血小板增多组IL-6浓度为(99±124)pg/ml,差异有统计学意义。血小板正常组肺结核病人较正常对照组CRP浓度偏高,ALB浓度偏低。而血小板增多组肺结核病人较血小板正常组肺结核病人CRP浓度偏高,而ALB浓度偏低。血清IL-6浓度与血小板计数和C-反应蛋白浓度都呈正相关(r1=0.56、r2=0.54),和白蛋白浓度有负相关性(r3=-0.34)。血小板增多组病人临床表现为体重减轻,发热和盗汗的概率较血小板正常组高。结论白细胞介素-6可能会引起肺结核病人血小板增多和促进急性时相反应。
Objective To investigate the role of interleukin-6 (IL-6) in patients with pulmonary tuberculosis induced by thrombocytopenia and acute phase reaction. Methods According to platelet count, 72 cases of pulmonary tuberculosis patients were divided into two groups: 37 cases with normal platelet count, 35 cases with platelet count increase, and 31 cases with normal control group. Serum IL-6, C-reactive protein (CRP), albumin (ALB) were measured. Results The concentration of IL-6 in normal platelet group was (38 ± 54) pg / ml and that in thrombocytosis group was (99 ± 124) pg / ml, the difference was statistically significant. The platelet normal control group had higher CRP concentration and lower ALB concentration than the normal control group. The thrombocytosis group of patients with pulmonary tuberculosis than normal group of patients with tuberculosis CRP concentration is high, while the ALB concentration is low. Serum IL-6 concentration was positively correlated with platelet count and C-reactive protein (r1 = 0.56, r2 = 0.54), and albumin concentration was negatively correlated (r3 = -0.34). Patients with thrombocytosis clinical manifestations of weight loss, fever and night sweats than the normal high probability of platelet group. Conclusion Interleukin-6 may cause thrombocytopenia in patients with pulmonary tuberculosis and promote acute phase response.