胶质瘤是神经系统原发肿瘤中最常见的类型,占神经系统原发肿瘤50%以上,其中弥漫性星形细胞瘤最为多见。依据瘤细胞核非典型性、核分裂像、血管新生和坏死四个指标,将其分为三级:低级别星形细胞瘤(WHOⅡ级)、间变型星形细胞瘤(WHOⅢ级)和胶质母细胞瘤 (WHOⅣ级)。弥漫性星形细胞瘤早期就向周围正常组织浸润性生长,形成卫星病灶,这些卫星病灶是复发的根源。本文就其分子生物学进展及抗血管新生疗法展望进行综述。 Glioma is the most common type of primary nervous system tumors, accounting for more than 50% of primary tumors of the nervous system, of which diffuse astrocytoma is the most common. According to the tumor atypical nucleus, mitosis, angiogenesis and necrosis of the four indicators, it is divided into three levels: low grade astrocytoma (WHO grade), astrocytoma (WHO Ⅲ grade) and gliadin Cell tumor (WHO Ⅳ grade). Diffuse astrocytoma early invasive tissue around the infiltration of normal growth, the formation of satellite lesions, these satellite lesions is the root cause of recurrence. This review summarizes advances in molecular biology and antiangiogenic therapies.