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目的 探讨 6项肿瘤标志辅助诊断肺癌的临床应用价值。方法 采用CEA、NSE、CYFRA 2 1 1、CA12 5、CA 19 9及CA 15 3联合检测 95例肺癌及 4 8例肺结核和肺内其他感染性疾病患者的血清。通过ROC曲线找到最佳临界值并比较几项肿瘤标志物的敏感性、特异性、准确率。结果 除CA 12 5外的其他 5项血清肿瘤标志物在肺癌及其对照组中差异具有显著性。CYFRA 2 1 1对鉴别肺腺癌和肺鳞癌 ,CEA及NSE对鉴别肺腺癌和肺小细胞癌具有一定意义。联合检测可提高诊断的敏感性和准确率。结论 除CA 12 5外的其他 5项血清肿瘤标志在肺癌的辅助诊断中具有重要意义
Objective To investigate the clinical value of six tumor markers in the diagnosis of lung cancer. Methods The serum levels of 95 cases of lung cancer and 48 cases of other pulmonary tuberculosis and other infectious diseases were detected by CEA, NSE, CYFRA 2 1 1, CA12 5, CA 19 9 and CA 15 3. Find the best cut-off value by ROC curve and compare the sensitivity, specificity and accuracy of several tumor markers. Results The other five serum tumor markers except CA 12 5 were significantly different in lung cancer and its control group. CYFRA 2 1 1 is of great significance for the differential diagnosis of lung adenocarcinoma and squamous cell carcinoma, CEA and NSE. Joint testing can improve the diagnostic sensitivity and accuracy. Conclusions The other 5 serum tumor markers except CA 12 5 are of great significance in the auxiliary diagnosis of lung cancer