论文部分内容阅读
目的分析2011年-2015年神经外科术后脑脊液培养阳性患者革兰阴性菌中肺炎克雷伯菌和鲍曼不动杆菌的分布和耐药性的变化情况。方法收集2011年-2015年首都医科大学附属北京天坛医院神经外科术后脑脊液培养阳性患者的革兰阴性菌种类分布及其药敏试验结果。结果脑脊液培养阳性分离株共2 033株,其中革兰阴性菌524株,占25.9%。肺炎克雷伯菌和鲍曼不动杆菌共有180株,其中鲍曼不动杆菌64株,肺炎克雷伯菌116株。而脑脊液培养分离得到的鲍曼不动杆菌和肺炎克雷伯菌对部分抗生素的敏感率总体呈下降趋势。结论由于多重耐药鲍曼不动杆菌与肺炎克雷伯菌的出现以及过度使用抗感染药物,使得神经外科术后颅内感染的细菌耐药情况越来越严重,必须严密监测细菌耐药和控制预防用药疗程和抗感染药物的滥用。
Objective To analyze the distribution and drug resistance of Klebsiella pneumoniae and Acinetobacter baumannii in Gram-negative bacteria in cerebrospinal fluid culture positive patients after neurosurgery from 2011 to 2015. Methods The distribution of Gram-negative bacteria in patients with cerebrospinal fluid culture positive after neurosurgery in Beijing Tiantan Hospital, Capital Medical University from 2011 to 2015 were collected and their susceptibility testing results were collected. Results A total of 2 033 strains of CSF-positive isolates were obtained, of which 524 were Gram-negative bacteria, accounting for 25.9%. There were 180 strains of Klebsiella pneumoniae and Acinetobacter baumannii, of which 64 Acinetobacter baumannii and 116 Klebsiella pneumoniae. However, the sensitivity of some antibiotics to Acinetobacter baumannii and Klebsiella pneumoniae isolated from cerebrospinal fluid culture showed an overall downward trend. Conclusion Due to the emergence of multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae, as well as the overuse of anti-infective drugs, the bacterial resistance to intracranial infections after neurosurgical surgery is becoming more and more serious. Therefore, it is necessary to closely monitor bacterial resistance and Control preventative medication and abuse of anti-infectives.