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目的 探讨 IFN- α对慢性乙型肝炎 (乙肝 )患者血清 IL- 2、SIL- 2 R水平的影响。方法 分别采用放射免疫法 (RIA)和双抗体夹心 EL ISA法检测 30例慢性乙肝患者干扰素治疗前后血清IL- 2、SIL- 2 R水平 ,以 30例健康献血员作为对照。结果 慢性乙肝患者血清 IL- 2和 SIL- 2 R水平明显高于对照组 (P <0 .0 5 )。干扰素治疗后 ,应答者 43% ,非应答者 5 7%。应答者 IL- 2水平明显高于非应答者 (P <0 .0 1) ;而 SIL- 2 R水平在应答者低于治疗前 (P >0 .0 5 ) ,在非应答者明显高于治疗前 (P <0 .0 1)。结论 干扰素参与慢性乙肝细胞免疫调控。
Objective To investigate the effects of IFN-α on serum IL-2 and SIL-2R levels in patients with chronic hepatitis B (hepatitis B). Methods Serum levels of IL-2 and SIL-2R in 30 patients with chronic hepatitis B before and after interferon treatment were measured by radioimmunoassay (RIA) and double antibody sandwich ELISA, respectively. Thirty healthy blood donors were used as controls. Results Serum levels of IL-2 and SIL-2R in patients with chronic hepatitis B were significantly higher than those in controls (P <0.05). After interferon treatment, 43% of responders and 57% of non-responders. The level of IL-2 in responders was significantly higher than that in non-responders (P <0.01), while the level of SIL-2R in responders was lower than before treatment (P> 0.05) Before treatment (P <0.01). Conclusion Interferon is involved in the immune regulation of chronic hepatitis B virus.