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目的：了解高原红细胞增多症（ＨＡＰＣ）骨髓红系组细胞增殖状况。方法：ＨＡＰＣ患者２５例，正常对照２２例身体健康者，应用造血祖细胞体外培养技术了解骨髓红系祖细胞（ＢＦＵ—Ｅ，ＣＦＵ—Ｅ）增殖能力，ＢＦＵ—Ｅ及ＣＦＵ—Ｅ对红细胞生成素（Ｅｐｏ）的反应能力。结果：ＨＡＰＣ患者骨髓ＢＦＵ—Ｅ，ＣＦＵ—Ｅ集落数分别高于正常对照。Ｅｐｏ对ＨＡＰＣ患者骨髓ＢＦＵ—Ｅ，ＣＦＵ—Ｅ刺激明显，与正常对照组比较ＢＦＵ—Ｅ集落数差异显著（Ｐ＜０．０５）；ＣＦＵ—Ｅ集落数差异显著（Ｐ＜０．０１）。结论：ＨＡＰＣ骨髓红系祖细胞增殖能力增强，对Ｅｐｏ敏感性增高。
Objective: To investigate the proliferation of bone marrow erythroid cells in high altitude polycythemia (HAPC). Methods: Twenty-five patients with HAPC and 22 healthy controls were enrolled in this study. The proliferation of bone marrow erythroid progenitor cells (BFU-E, CFU-E) was evaluated by in vitro culture of hematopoietic progenitor cells. BFU-E and CFU- Epo response ability. Results: The bone marrow BFU-E and CFU-E colonies in HAPC patients were higher than those in normal controls respectively. Epo stimulated BFU-E and CFU-E in bone marrow of patients with HAPC significantly (P <0.05). The number of CFU-E colonies was significantly different from that of normal controls (P <0.01). Conclusion: HAPC erythroid progenitor cells proliferate more and have a higher sensitivity to Epo.