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目的观察天麻素对大鼠大脑中动脉栓塞后癫痫发作率和病死率的影响及其对脑缺血后神经功能的保护作用。方法将150只SD雄性大鼠随机分为假手术组、模型组和天麻素治疗组,每组50只,模型组和天麻素治疗组采用线栓法制备大脑中动脉栓塞模型,天麻素治疗组提前给予100 mg/kg的天麻素预处理,假手术组仅暴露而不闭塞大脑中动脉,术后精心护理,评估3组术后24 h内癫痫发作率和病死率。结果模型组和天麻素治疗组大鼠脑缺血后癫痫的发作率和病死率均高于假手术组,天麻素治疗组癫痫发作率和病死率低于模型组,差异均有统计学意义(P<0.05)。结论天麻素可降低大脑中动脉栓塞后癫痫发作率和病死率,发挥脑保护作用。
Objective To observe the effect of gastrodin on epileptic seizure rate and mortality after middle cerebral artery occlusion in rats and its neuroprotective effect after cerebral ischemia. Methods 150 male Sprague-Dawley rats were randomly divided into sham operation group, model group and gastrodin treatment group, with 50 rats in each group. The model group and gastrodin treatment group were given middle cerebral artery occlusion (MCAO) Gastrodin 100 mg / kg was pretreated in advance. The sham operation group was exposed without occlusion of the middle cerebral artery. After careful nursing, the seizure rate and mortality rate within 24 h after operation were evaluated. Results The incidence and mortality of epilepsy after cerebral ischemia in model group and gastrodin treatment group were higher than those in sham operation group. The seizure rate and mortality rate in gastrodin treatment group were lower than those in model group (P < P <0.05). Conclusion Gastrodin can reduce the epileptic seizure rate and mortality after middle cerebral artery occlusion and exert cerebral protection.