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目的:探讨幽门螺杆菌(Hp)感染与小儿胃炎和十二直肠溃疡的关系。方法:对186例有消化道症状的儿童进行内窥镜检查,并取胃窦部活检组织作细菌培养和组织病理学检查。结果:内镜检查有消化道疾病的患儿178例,病变检出率为95.7%(178/186),Hp感染检出80例,阳性率为44.9%。儿童Hp感染率与年龄呈显著正相关(r=0.94,P=0.012);慢性中度炎症比轻度炎症者幽门螺杆菌感染率明显增高,重度炎症比中度炎症幽门螺杆菌感染率明显增高;少数民族Hp感染率为56.3%(45/80),汉族为35.7%(35/98),差异有统计学意义。Hp感染患儿所患上消化道疾病的发生率与年龄呈显著正相关(r=0.990,P=0.003)。结论:(1)小儿Hp感染率随年龄增长而递增;(2)胃粘膜病变越重Hp阳性率越高;(3)少数民族儿童的Hp感染率高于汉族。
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and gastritis in children and duodenal ulcer. Methods: 186 children with gastrointestinal symptoms were examined by endoscopy. The gastric sinus biopsies were taken for bacterial culture and histopathological examination. Results: There were 178 cases of gastrointestinal diseases in endoscopy. The detection rate was 95.7% (178/186). There were 80 cases of Hp infection, the positive rate was 44.9%. The infection rate of Hp in children was positively correlated with age (r = 0.94, P = 0.012). The infection rate of Helicobacter pylori in chronic moderate inflammation was significantly higher than that in mild inflammation, and the infection rate of Helicobacter pylori in severe inflammation was significantly higher than that in moderate inflammation ; Hp infection rate was 56.3% (45/80) in ethnic minorities and 35.7% (35/98) in Han nationality, the difference was statistically significant. The incidence of upper gastrointestinal diseases in children with Hp infection was significantly and positively correlated with age (r = 0.990, P = 0.003). Conclusions: (1) The prevalence of Hp infection in children increases with age; (2) the higher the prevalence of Hp in patients with gastric mucosal lesions is higher; (3) The prevalence of Hp infection in ethnic minority children is higher than that in Han nationality.