自1974年Bottazzo首次发现胰岛细胞抗体(ICA)以来,人们在这方面做了不少工作。现在普遍认为,胰岛素依赖型糖尿病(IDDM)的发病和胰岛细胞抗体的产生有着密切的关系,甚至认为IDDM是一种自身免疫性疾病,它的发生与以下三个因素有关。首先,是遗传易感性,现已表明和HLA有关;共次,是一些激发因素的刺激,如病毒感染;最后,是机体免疫功能的失调,导致胰岛细胞自身抗体的生成,继之以胰岛细胞的破坏,体内胰岛素缺 A lot has been done in this area since Bottazzo first discovered islet cell antibody (ICA) in 1974. It is now widely accepted that the incidence of insulin-dependent diabetes mellitus (IDDM) is closely related to the production of islet cell antibodies. IDDM is even considered an autoimmune disease and its occurrence is related to the following three factors. First, genetic susceptibility has been shown to be associated with HLA; in total, stimuli such as viral infections are stimulated by a number of stimuli; and finally, dysregulation of immune function leads to the production of islet cell autoantibodies followed by islet cells The destruction of the body of insulin deficiency