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前言头孢克肟(Cefixime)是第三代口服头孢菌素。我国已经将头孢克肟列入“九五”及2010年医药科技发展规划中[1]。头孢克肟传统合成方法有以下两种:一种以7—ACA为原料,与水杨醛缩合后经过酯化、氯化等反应制得;另一种以脱乙
Preface Cefixime is the third generation oral cephalosporin. China has included cefixime in the “95” and in 2010 the development plan of medical science and technology [1]. Cefixime traditional synthesis methods are the following two: a 7-ACA as raw materials, with salicylaldehyde after esterification, chlorination and other reactions obtained; the other to de-et