Hoyer 等报道用环孢菌素(Cyclospo-rin)治疗儿童特发性肾病综合征(INS)的经验。18个月来,本文作者已用环孢菌素治疗13例对类固醇无效的成人 INS。微小病变型(MCD)或局灶节段性肾小球硬化症(FSGS)INS,用类固醇治疗并非总有效,有的病人对类固醇依赖,有的病人则对类固醇耐药,主要见于 FSGS 组,并有发展成肾功衰竭的危险。长期大剂量类固醇治疗可并发感染、代谢性疾病及血栓栓塞。烷化剂有时有效 Hoyer et al. Reported on the experience of using cyclosporin to treat children with idiopathic nephrotic syndrome (INS). For 18 months, the authors of this article have used cyclosporin to treat 13 adult INS patients that are not effective on steroids. Micro-lesion (MCD) or focal segmental glomerulosclerosis (FSGS) INS, steroid treatment is not always effective, some patients steroid dependence, while others are steroid resistant, mainly seen in the FSGS group, And there is the risk of developing renal failure. Long-term high-dose steroid therapy can be complicated by infection, metabolic diseases and thromboembolism. Alkylating agents are sometimes effective