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目的 :研究育龄妇女 To RCH系列感染及其与异常妊娠结局的关系。方法 :采用间接 EL ISA对 2 5 0例育龄妇女作 4种 To RCH病原体抗体检测 ,部分 Ig M(或 Ig G)阳性病例并作 PCR检测。对其中 2 1例异常妊娠结局的胚胎组织块作了 PCR检测和对 10例异常新生儿作了血清学诊断。结果 :2 5 0例育龄妇女 To X、Rub V、CMV、HSVIg M阳性率分别为 8.0 %、12 .8%、6 .8%和 8.4% ,并发现同一病例有两种或两种以上病原体同时感染的情况 ,PCR结果与之基本一致。2 1例与 To RCH感染有关异常妊娠结局 (流产、早产、死胎、先天缺陷 )孕妇均有 To RCH中的一种、2种或 2种以上病原体感染 ,从死胎脑组织块、人工流产混合物的 PCR结果与之吻合。 10例新生儿脑炎血清与对应母亲血清抗体检测表明 ,垂直传播率 To X与 CMV分别为 5 0 %和 40 %。结论 :To RCH系列感染与异常妊娠结局的关系十分密切。
Objective: To study To RCH infection in women of childbearing age and its relationship with abnormal pregnancy outcome. Methods: Four kinds of To RCH pathogen antibodies were detected in 250 women of childbearing age by indirect ELISA, and some IgM (or IgG) positive cases were detected by PCR. PCR was performed on 21 cases of embryo tissue abnormalities and 10 cases of abnormal neonates were diagnosed serologically. Results: The positive rates of To X, Rub V, CMV and HSVIg M in 250 women of childbearing age were 8.0%, 12.8%, 6.8% and 8.4% respectively. Two or more pathogens were found in the same case At the same time the infection, PCR results and basically the same. 21 cases of To RCH infection related to abnormal pregnancy outcomes (miscarriage, premature birth, stillbirth, birth defects) Pregnant women have ToRCH in one, two or more pathogens infection, dead fetal brain tissue blocks, abortion mixture The PCR results match. 10 cases of neonatal encephalitis serum and corresponding maternal serum antibody test showed that the vertical transmission rate To X and CMV were 50% and 40%. Conclusion: The relationship between To RCH infection and abnormal pregnancy outcome is very close.