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术后病人的淋巴细胞在试管内对自身黑色素瘤细胞有细胞毒性反应,但瘤细胞的可溶性浸出物可抑制淋巴细胞的这种反应。用患者的淋巴细胞与不同量的瘤浸出物一起孵育,而后将淋巴细胞加入肿瘤靶细胞48小时后检测靶细胞的减少率,同时以正常人淋巴细胞作对照。用黑色素瘤浸出物处理过的淋巴细胞同未处理的淋巴细胞相比,前者使靶细胞的减少率降低甚至消失。黑色素瘤浸出物虽抑制黑色素瘤病人的淋巴细胞对黑色素瘤靶细胞的细胞毒性,但不能抑制结肠癌病人的淋巴细胞对同种异体的结肠癌细胞的细胞毒性反应。同样,结肠癌浸出物能抑制结肠癌病人的淋巴细胞,而对黑色素瘤病人的
The patient’s lymphocytes have a cytotoxic reaction to their own melanoma cells in vitro, but the soluble extracts of the tumor cells can inhibit this reaction of lymphocytes. The patient’s lymphocytes were incubated with different amounts of tumor extracts, and then lymphocytes were added to the tumor target cells for 48 hours to detect the reduction rate of the target cells, while normal human lymphocytes were used as controls. The lymphocytes treated with the melanoma leachate reduced or even disappeared the reduction rate of the target cells compared with the untreated lymphocytes. Although melanoma lecithin inhibits the cytotoxicity of lymphocytes of melanoma patients on melanoma target cells, it does not inhibit the cytotoxic response of lymphocytes of colon cancer patients to allogeneic colon cancer cells. Similarly, colon cancer leukemia inhibits lymphocytes in patients with colon cancer, and in patients with melanoma