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美国Nebraska大学医学中心对32例纵隔何杰金氏病(HD)患者进行了回顾性分析。Ⅰ期2例,Ⅱ期19例,Ⅲ期8例,Ⅳ期3例,其中19例实施了分期诊断性剖腹及脾切除术。病理证实:结节硬化型24例,混合细胞型5例,淋巴细胞为主型2例,没有分类1例。对限于右颈和/或腋窝受累者,仅给予斗蓬野照射,左颈和纵隔受侵者给予斗蓬野和腹主动脉旁加脾门区照射。单纯放疗14例,放疗合并化疗18例,其中10例放疗前行ChIVPP方案6个周期,4例放疗前后MOPP方案各3个周期,余4例为放疗合并上述方案的不规则化疗。纵隔情况的观察根据正侧位胸片,除疗前、疗中外,疗后第一年每间隔1个月,第二年每间隔3个月,以后每间隔
The University of Nebraska Medical Center in the United States conducted a retrospective analysis of 32 patients with mediastinal Hodgkin’s disease (HD). There were 2 cases in stage I, 19 cases in stage II, 8 cases in stage III, and 3 cases in stage IV. Among them, 19 cases underwent staged diagnostic laparotomy and splenectomy. Pathology confirmed: 24 cases of nodular sclerosis, mixed cell type 5 cases, lymphocyte type 2 cases, no classification of 1 case. For persons confined to the right neck and/or axilla, only the cappuccino field was irradiated, and the left neck and mediastinum were inflicted to the caput and the abdominal aorta plus the splenic region. There were 14 cases of radiotherapy alone and 18 cases of radiotherapy combined with chemotherapy. Among them, 10 cases were treated with 6 cycles of ChIVPP regimen before radiotherapy, 4 cases were treated with 3 cycles of MOPP regimen before and after radiotherapy, and the remaining 4 cases were radiotherapy combined with the above regimen of irregular chemotherapy. The mediastinal situation was observed according to the lateral radiograph, except for pretreatment, treatment, and external treatment. The interval was 1 month at the first year after treatment, and 3 months at the interval of the second year after each interval.