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用嗜热菌酶酶促合成了一系列含门冬氨酸、谷氨酸的肽。实验证明,缩合反应中羧基组份中的门冬氨酸β-羧基或谷氨酸γ-羧基毋需保护。同时也研究了邻近氨基酸残基对缩合反应的影响。
A series of peptides containing aspartic acid and glutamic acid were enzymatically synthesized by thermophilic enzyme. Experiments show that the carboxyl component of the condensation reaction aspartate β-carboxyl or glutamic acid γ-carboxyl without protection. The effect of adjacent amino acid residues on the condensation reaction was also studied.