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目的探讨腹腔镜胃癌根治术对机体免疫功能的影响。方法 70胃癌患者分为腹腔镜组及开腹组各35例,比较两组的手术时间、术中出血量、肛门排气时间、平均住院时间、并发症发生率;以及两组患者术前及术后第7天IL-6、CRP的变化。结果腹腔镜组患者的手术时间、术中出血量、住院时间、肛门排气时间及并发症发生率分别与对照组比较,差异具有统计学意义(P<0.05)。开腹组患者IL-6术后第3天、术后第7天均较术前明显升高,且显著高于腹腔镜组(P<0.05)。术后第3天两组患者的CRP水平较术前明显升高,术后第7天恢复正常。且开腹组CRP水平术后第3天较腹腔镜明显升高。结论腹腔镜胃癌根治术较开腹手术创伤小、出血少、并发症少,且对患者机体免疫功能的影响小于开腹手术。
Objective To investigate the effect of laparoscopic radical gastrectomy on immune function. Methods 70 patients with gastric cancer were divided into laparoscopic group and laparotomy group of 35 cases, the operation time, intraoperative blood loss, anal exhaust time, average length of stay, complication rate; the two groups of patients before and Changes of IL-6 and CRP on the 7th postoperative day. Results The operation time, intraoperative blood loss, hospitalization time, anal exhaust time and complication rate in laparoscopic group were significantly different from those in control group (P <0.05). In the open group, the IL-6 level at 3 days and 7 days after operation was significantly higher than that before operation (P <0.05). On the third day after operation, CRP levels in both groups were significantly higher than those before operation, and returned to normal on the 7th day after operation. And open group CRP levels were significantly higher than laparoscopy on the 3rd day after operation. Conclusions Laparoscopic radical gastrectomy has less trauma, less bleeding and fewer complications than laparotomy, and has less effect on the immune function of patients than laparotomy.