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Celiprolol为新型选择性心血管β受体拮抗剂,已被用于治疗原发性高血压。作者通过文献复习,探讨了该药的疗效及安全性。一组2311例各期高血压病人的研究结果表明,Celiprolol能显著降低收缩压和舒张压。尽管有效剂量变异很大,但疗效是肯定的。本药每日剂量范围200～600mg。有人对84例轻中度高血压病人行安慰剂治疗3周后随机分组给予安慰剂或Celiprolol 400mg/日治疗。4周后安慰剂组的血压无明显变化,而Celiprolol组的血压则明显下降,且在清醒状态下作用明显,睡眠时作用缓和。持续血压监测结果证实,以本药顿服法治疗高血压有效。其疗效与
Celiprolol, a new selective cardiovascular beta-receptor antagonist, has been used to treat essential hypertension. The author reviewed the literature to explore the efficacy and safety of the drug. A series of 2311 patients with various stages of hypertension showed that Celiprolol significantly reduced systolic and diastolic blood pressure. Although the effective dose variation is large, but the effect is positive. The daily dose of the drug 200 ~ 600mg. Eighty-four patients with mild-to-moderate hypertension were randomized to placebo or Celiprolol 400 mg daily for 3 weeks after placebo. There was no significant change in blood pressure after 4 weeks of treatment in the placebo group, while the blood pressure of the Celiprolol group was significantly decreased, and the effect was obvious in the awake state and the effect was alleviated during sleep. Continuous blood pressure monitoring results confirmed that the drug Dayton treatment of hypertension effective. Its efficacy and