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目的探究肾素血管紧张素转换酶抑制剂/受体阻滞剂(ACEI/ARB)治疗是否影响高血压伴心房颤动(AF)患者血清结缔组织生长因子(CTGF)、碱性成纤维细胞生长因子(bFGF)水平。方法回顾分析2010年9月至2012年2月中山大学孙逸仙纪念医院心血管内科收治的高血压病例,将高血压伴AF患者85例以及窦性心律(简称窦律)患者54例按是否接受ACEI/ARB治疗分成窦律对照组26例、治疗组28例以及AF对照组42例和治疗组43例,测定血清中CTGF、bFGF水平。结果 AF对照组血清CTGF、bFGF均显著高于窦律对照组(P均<0.05);窦律对照组与治疗组间血清CTGF、bFGF差异均无统计学意义(P均>0.05);AF治疗组血清CTGF、bFGF均明显低于对照组(P均<0.05)。结论高血压伴AF患者血清CTGF、bFGF均升高,ACEI/ARB治疗可降低其CTGF和bFGF水平。
Objective To investigate whether the treatment of renin angiotensin converting enzyme inhibitor / receptor blocker (ACEI / ARB) affects the expression of serum connective tissue growth factor (CTGF), basic fibroblast growth factor (bFGF) levels. Methods From September 2010 to February 2012, Sun Yat-sen Memorial Hospital of Sun Yat-sen Memorial Hospital of hypertension admitted cases, the hypertensive patients with AF and 85 patients with sinus rhythm (referred to as sinus rhythm) 54 patients according to whether ACEI / ARB were divided into sinus rhythm control group (n = 26), treatment group (n = 28), AF control group (n = 42) and treatment group (43 cases). Serum levels of CTGF and bFGF were measured. Results The serum levels of CTGF and bFGF in AF group were significantly higher than those in sinus rhythm control group (all P <0.05). There was no significant difference in serum CTGF and bFGF between control group and treatment group (all P> 0.05) Serum levels of CTGF and bFGF were significantly lower than those of the control group (all P <0.05). Conclusion Serum levels of CTGF and bFGF are both elevated in patients with hypertension and AF. ACEI / ARB treatment can reduce the levels of CTGF and bFGF.