目的报告1例短期接触铅致重度铅中毒病例的发病情况、临床表现及治疗转归。方法回顾性分析本院近期收治了1例慢性重度铅中毒病人的临床资料。结果病人接触铅烟8个月后即出现铅麻痹,引起慢性重度铅中毒。结论铅麻痹与铅接触时间、尿铅浓度不一定成正比关系,可能存在明显的个体差异。尽早使用鼠神经生长因子可能是有效治疗方法之一。 Objective To report the incidence, clinical manifestation and treatment outcome of one case of severe lead poisoning caused by lead exposure to lead. Methods The clinical data of one patient with chronic severe lead poisoning admitted to our hospital recently were retrospectively analyzed. Results Lead poisoning occurred 8 months after exposure to lead smoke and caused chronic severe lead poisoning. Conclusion lead palsy and lead exposure time, urine lead concentration is not necessarily proportional relationship, there may be significant individual differences. Early use of murine nerve growth factor may be one of the effective treatments.