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关于控制正常细胞增殖的抑制物的初期报告见于50年代中期。稍后,Ballough 提示了关于内源性特异性细胞增殖抑制物的基本原理,并称这种抑制物为抑素(chalone)。以后又出现了一些从动物和人的很多器官和组织分离出抑素的报道。这些观察大大充实和发展了抑素的理论。关于抑素的基本原理可以归纳如下:1.动物和人的任何增殖中的组织的成熟细胞均向周围环境分泌细胞增殖抑制物——抑素。
Initial reports on inhibitors that control normal cell proliferation were found in the mid-1950s. Later, Ballough suggested the basic principle of endogenous cell proliferation inhibitors and called the inhibitor chalone. Later, there have been reports of the isolation of somatostatin from many organs and tissues of animals and humans. These observations greatly enriched and developed the theory of Suppression. The basic principles of Suppressor can be summarized as follows: 1. The mature cells of any proliferating tissues of animals and humans secrete inhibitors of cell proliferation to the surrounding environment, somatostatin.