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目的 通过甲孕酮与化疗合用的方法 ,探讨晚期胃癌化疗中改善生活质量的有效措施。方法 采用甲孕酮与VDF化疗方案联合应用、并以单纯VDF方案化疗作为对照组进行临床研究 ,通过观察分析治疗组和对照组之间的生活质量差异评价效果。结果 VDF化疗加甲孕酮组的化疗后进食量增加占 75 .0 %、无变化占 2 5 %、无 1例食欲减退 ,而单纯VDF化疗组化疗后食欲减退为 5 9.4%、无变化 40 .6 %、无食欲增加病例 ;VDF化疗加甲孕酮组化疗后体重增加、无变化、减少分别为34.4%、5 3.1%和 12 .5 %,单纯VDF化疗组则分别为 3.1%、31.3%和 6 5 .6 %;上述结果两组间均有显著性差异。化疗副反应两组之间对比 ,VDF +甲孕酮组的厌食反应程度明显较单用VDF组轻而且发生率低 (P <0 .0 1) ,其它化疗副反应两组之间无明显差异 (P >0 .0 5 )。结论 甲孕酮与化疗并用 ,能够显著改善晚期胃癌病人化疗后的生活质量 ,对树立病人战胜癌症的信心 ,提高病人对化疗的承受能力和提高化疗效果具有重要应用价值。
Objective To discuss the effective measures to improve the quality of life in patients with advanced gastric cancer through medroxyprogesterone acetate combined with chemotherapy. Methods Medroxyprogesterone acetate and VDF chemotherapy regimen were used in combination with VDF chemotherapy as a control group for clinical study. The difference in quality of life between treatment group and control group was evaluated by observation and analysis. Results After VDF chemotherapy and progesterone treatment, the food intake increased 75.0% after chemotherapy, no change accounted for 25% and no one had loss of appetite. Compared with VDF chemotherapy alone, the loss of appetite after chemotherapy was 5 9.4% and no change 40. 6% and no increase in appetite. The body weight of VDF chemotherapy plus progesterone group increased 34.4%, 51.1% and 12.5% respectively after chemotherapy, while those in VDF chemotherapy group were 3.1% and 31.3% respectively And 65.6% respectively. There was a significant difference between the two groups in the above results. Chemotherapy side effects between the two groups, VDF + Medroxyprogesterone anorexia reaction was significantly less than the VDF alone group and the incidence was low (P <0.01), other chemotherapy side effects no significant difference between the two groups (P> 0.05). Conclusions Medroxyprogesterone acetate combined with chemotherapy can significantly improve the quality of life of patients with advanced gastric cancer after chemotherapy, which has important application value in setting patient’s confidence in defeating cancer, improving patients’ tolerance to chemotherapy and improving chemotherapy effect.