论文部分内容阅读
目的探讨血清白细胞介素-1受体拮抗蛋白(IL-1Ra)在早期诊断急性心肌梗死(AMI)患者中的临床价值。方法比较IL-1Ra、肌红蛋白(MYO)、肌钙蛋白I(cTnI)、肌酸激酶同功酶(CK-MB)四种物质定量检测对诊断发病6h内的AMI的敏感性、特异性和准确性。结果 AMI组IL-1Ra水平高于非急性心肌梗死组和正常对照组(P均<0.01);AMI组和非急性心肌梗死组患者血清IL-1Ra含量进行Logistic回归分析得知,IL-1Ra诊断AMI的最佳临界值为210pg/ml。IL-1Ra诊断发病3h和6h内的AMI的敏感性显著高于cTnI和CK-MB(P<0.05),特异性差异则无统计学意义(P>0.05),诊断准确性高于MYO、cTnI和CK-MB。结论 IL-1Ra在AMI患者中早期升高对发病<3h的AMI患者有诊断意义,提示检测IL-1Ra可作为早期诊断AMI的一个重要的辅助指标。
Objective To investigate the clinical value of serum interleukin-1 receptor antagonist (IL-1Ra) in the early diagnosis of acute myocardial infarction (AMI). Methods The sensitivity and specificity of quantitative detection of IL-1Ra, myoglobin (MYO), troponin I (cTnI) and creatine kinase isoenzyme (CK-MB) And accuracy. Results The levels of IL-1Ra in AMI group were significantly higher than those in non-AMI group and normal control group (all P <0.01). Logistic regression analysis showed that serum IL-1Ra level in AMI group and non-AMI group was significantly higher than that in non-AMI group The best cut-off value for AMI is 210 pg / ml. The sensitivity of AMI in 3h and 6h after IL-1Ra diagnosis was significantly higher than that of cTnI and CK-MB (P <0.05), but the specificity was not statistically significant (P> 0.05). The accuracy of diagnosis was higher than that of MYO and cTnI And CK-MB. Conclusion IL-1Ra in early AMI patients with elevated disease in patients with onset of AMI 3h diagnosis, suggesting that the detection of IL-1Ra can be used as an early diagnosis of AMI is an important auxiliary indicators.