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综述了近十年来具有表皮生长因子受体(EGFR)抑制活性的喹唑啉衍生物的国内外研究进展,按照喹唑啉环上不同位置上的取代基类型分为四类,介绍了化合物不同位置上取代基对此类化合物生物活性的影响,并对其发展趋势和应用前景作了展望.
This review summarizes the progress of quinazoline derivatives with epidermal growth factor receptor (EGFR) inhibitory activity in recent ten years. The research progress is divided into four groups according to the types of substituents at different positions on the quinazoline ring. Position of the substituents on the biological activity of these compounds, and its development trends and prospects for the future.