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采用挤压法制备了海藻酸钠/羽毛蛋白(SA/FK)复合微球。用FTIR和黏度法研究了SA/FK体系的交互作用、探讨了不同制备条件(FK用量、交联剂质量分数、交联时间)、溶胀溶液性质(pH、温度、离子强度)对溶胀性能的影响。结果表明,复合体系的交互作用是静电为主,氢键次之。随着时间延长,溶胀速率变缓,最终达到溶胀平衡。当m(FK)/m(SA)=0.60、w(CaCl2)=7%、交联时间为60 min时,复合微球网络结构最紧密,溶胀速率最低,平衡溶胀率分别为0.6、0.6、0.9。pH由1增加至7,平衡溶胀率仅从0.9升至1.1,当pH=13时,平衡溶胀率升至3.8。温度由30℃提高至45℃,平衡溶胀率从0.6升至0.9。离子强度由0增加至0.6 mol/L,平衡溶胀率从1.1升至13.8。SA/FK复合微球具有pH/温度/离子强度敏感性,有望实现新型智能缓释微球的开发。
Alginate / feather protein (SA / FK) composite microspheres were prepared by extrusion. The interaction of SA / FK system was studied by FTIR and viscometry. The effects of different preparation conditions (FK content, crosslinker mass fraction, crosslinking time), swelling solution properties (pH, temperature and ionic strength) influences. The results show that the interaction of the composite system is mainly electrostatic, followed by hydrogen bonds. As time goes on, the swelling rate becomes slower and finally the swelling balance is reached. The microstructure of the composite microspheres was the most compact with the lowest swelling rate when the ratio of m (FK) / m (SA) = 0.60, w (CaCl2) = 7% and the crosslinking time of 60 min. The equilibrium swelling rates were 0.6,0.6, 0.9. The pH increased from 1 to 7, the equilibrium swelling rate increased from 0.9 to 1.1, and the equilibrium swelling rate rose to 3.8 at pH = 13. The temperature was raised from 30 ° C to 45 ° C and the equilibrium swelling rate increased from 0.6 to 0.9. The ionic strength increased from 0 to 0.6 mol / L, and the equilibrium swelling rate increased from 1.1 to 13.8. SA / FK composite microspheres with pH / temperature / ionic strength sensitivity, is expected to achieve a new type of intelligent sustained-release microspheres development.