本文建立同时测定外感风痧颗粒中原儿茶酸、原儿茶醛、绿原酸、咖啡酸4种成分的HPLC方法.色谱柱为依利特Hypersil C18柱(250 mm×4.6 mm,5μm);流动相为乙腈-0.2％磷酸,梯度洗脱,流速1.0 mL·min-1;柱温25℃.结果显示:4种指标成分分离效果良好,原儿茶酸在3.672～33.048μg·mL-1、原儿茶醛在1.236～11.124μg·mL-1、绿原酸在9.2～82.8μg·mL-1、咖啡酸在1.488～13.392μg·mL-1线性关系良好;平均加样回收率均为97.6％～103.3％.本方法准确、灵敏、可靠,重现性较好,可用于外感风痧颗粒的质量控制.“,”In this paper，an HPLC method was established for the simultaneous determination of four compovents of protocatechuic acid，protocatechuic aldehyde，chlorogenic acid and caffeic acid in Waiganfengsha granule. The chromatographic separation was achieved on a Hypersil C18(250 mm×4.6 mm，5μm) column with acetonitrile -0.2% phosphoric acid as mobile phases for gradient elution，at the flow rate of 1.0 mL·min-1. The column temperature was 25℃.The results showed that the four active components were well separated and showed good linear relationship when protocatechuic acid was 3.672-33.048μg·mL-1，protocatechuic aldehyde was 1. 236-11. 124μg·mL-1，chlorogenic acid was 9. 2- 82. 8μg·mL-1，and caffeic acid was 1.488-13.392μg·mL-1.The average recovery rates were all between 97.6% and 103.3 %.The method is accurate，sensitive，credible and repeatable and can be applied to the quality control of Waiganfengsha granule.