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目的探讨停供碘盐对饮用水碘含量为5.0～50.0μg/L的人群碘营养水平的影响,提出碘缺乏病地区划分标准的外环境饮用水碘含量的切点值。方法采用现场干预实验的方法,在内蒙古和河南两省、区选择生活饮用水碘含量为5.0～50.0μg/L的居民户作为干预对象,进行停供碘盐现场干预,采集8～13岁学龄儿童1、8～49岁育龄妇女以及18～60岁成年男子干预前和干预后60 d的一次随机尿样进行尿碘检测。结果干预前学龄儿童、育龄妇女以及成年男子的尿碘中位数分别为258.5μg/L2、97.0μg/L、301.9μg/L,干预60 d后尿碘中位数分别为160.6μg/L、160.8μg/L、154.6μg/L,均较干预前显著下降(P<0.05),且处于碘适宜水平。结论停供碘盐后生活在非高碘地区且饮用水碘含量为5.0～50.0μg/L的人群碘营养水平为适宜,可将碘缺乏病地区划分标准中外环境饮用水碘含量切点值确定为5.0μg/L。
Objective To investigate the effect of stopping supplying iodized salt on the iodine nutrition of drinking water with iodine content of 5.0 ~ 50.0μg / L, and to propose the cut-off value of iodine content in drinking water of external environment for iodine deficiency disorders. Methods By means of field intervention experiments, residents in Inner Mongolia and Henan Provinces, whose iodine content was 5.0-50.0 μg / L, were chosen as interventions. On-site intervention for stopping iodized salt was conducted. Eight to 13-year-old school-age children Urinary iodine was detected in a randomized urine sample of children aged 18-49 years and women aged 18-60 years before and 60 days after intervention. Results The median urinary iodine of 258.5μg / L, 97.0μg / L and 301.9μg / L respectively before school children, women of childbearing age and adult men were 160.6μg / L and 60.6μg / L respectively after 60 days of intervention, 160.8μg / L and 154.6μg / L, respectively, which were significantly lower than those before intervention (P <0.05), and were at the appropriate levels of iodine. Conclusions The iodine nutrition level of the population living in non-iodine area after iodized salt stop drinking and the iodine content of drinking water 5.0 ~ 50.0μg / L is suitable, and the iodine cut point of drinking water iodine deficiency area can be divided 5.0 μg / L.