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目的:研究地黄梓醇不同给药方式药物代谢动力学.方法:分别以肌肉注射,静脉注射,灌胃给药对大鼠给药,给药后通过HPLC测定血浆浓度,绘制浓度曲线,通过DAS 3.5计算药物代谢动力学参数.结果:梓醇的肌肉注射和灌胃生物利用度分别为49%和72%,半衰期分别为1.4h和0.8h.结论:药物代谢动力学参数及绝对生物利用度表明,梓醇在灌胃,肌注2种给药途径的体内生物利用度为肌注大于灌胃.
OBJECTIVE: To study the pharmacokinetics of radix isatidis in different administration modes.Methods: The rats were given intramuscular, intravenous and intragastric administration respectively, the plasma concentration was determined by HPLC after administration, the concentration curve was drawn, 3.5 Pharmacokinetic parameters were calculated.Results: The intramuscular and intragastric bioavailability of catalpol were 49% and 72%, respectively, and the half-lives were 1.4h and 0.8h respectively.CONCLUSIONS: The pharmacokinetic parameters and absolute bioavailability Showed that catalpol in the gavage, intramuscular injection of two routes of administration for the bioavailability of intramuscular injection than gavage.