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目的:探讨近年我国肝硬化病因的特点及其变化。方法:回顾性分析北京协和医院1994年1月至2002年2月719例肝硬化住院病人的病因。结果:乙型病毒性肝炎后肝硬化413例(57.44％),丙型病毒性肝炎后肝硬化40例(5.56％),酒精性肝硬化50例(6.96％),自身免疫病引起者48例(6.68％),另有57例(7.93％)同时存在乙型病毒性肝炎和酒精因素。按时期分为前4年和后4年分别分析。显示酒精性肝硬化由4％增加到9.76％,自身免疫性肝硬化由4％增加到9.21％,均呈随时间增加趋势。本组病人中99例(13.77％)合并肝癌,其中97例与病毒性肝炎相关。结论:病毒性肝炎(主要为乙肝)仍是我国肝硬化的最主要病因,而洒精性和自身免疫性肝硬化的发病率呈上升趋势,应引起足够的重视。
Objective: To explore the etiology and changes of cirrhosis in our country in recent years. Methods: A retrospective analysis of Beijing Union Medical College Hospital from January 1994 to February 2002 719 cases of cirrhosis inpatients etiology. Results: 413 cases of cirrhosis (57.44%) after hepatitis B, 40 cases (5.56%) of hepatitis C after cirrhosis, 50 cases (6.96%) of alcoholic cirrhosis, 48 cases of autoimmune disease (6.68%). Another 57 patients (7.93%) had both hepatitis B and alcohol. According to the period is divided into four years and four years after the analysis. Showed alcoholic cirrhosis from 4% to 9.76%, autoimmune cirrhosis from 4% to 9.21%, all showed an increasing trend over time. 99 patients (13.77%) in this group had liver cancer, of which 97 were associated with viral hepatitis. Conclusions: Viral hepatitis (mainly hepatitis B) is still the most important cause of cirrhosis in our country. However, the incidence of splenomegaly and autoimmune cirrhosis is on the rise and should be given enough attention.