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用电镜钙细胞化学定位法和酶组织化学亚微数字图像分析系统，观察了断奶ｄ１起，分别给饮用１０和３０ｍｇ·Ｌ－１Ｐｂ２＋水３个月的幼鼠脑组织．发现血铅浓度为对照组１．６５倍时，细胞内钙分布和超微结构无明显变化．血铅浓度为对照组２．４５倍时，脑铅含量增加，Ｃａ２＋－ＡＴＰ酶活性降低，磷脂酶活性增加，钙细胞化学观察见各种细胞的钙分布和超微结构均已发生了变化．结果显示：３０ｍｇ·Ｌ－１的铅染毒量即能引起幼鼠脑皮质区细胞钙代谢的恶性循环，如不给予阻断可能导致细胞进一步损伤．
Electron microscopic calcium cytochemistry and enzymatic histochemical submicro-digital image analysis system were used to observe the brain tissue of daunting rats, which were dosed for 10 and 30 mg · L-1Pb2 + 3 months after weaning respectively. Blood lead concentrations found 1.65 times the control group, the intracellular calcium distribution and ultrastructure did not change significantly. Blood lead concentration of 2.45 times the control group, the brain lead content increased, Ca2 + -ATPase activity decreased, phospholipase activity increased, calcium cell chemistry observed various cell calcium distribution and ultrastructure have been changed. The results showed that the lead exposure dose of 30 mg · L-1 could cause a vicious cycle of calcium metabolism in the cortex of young rats. If left unchecked, the cells could be damaged further.