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目的探讨5-FU缓释粒子治疗恶性腹腔积液的疗效及毒副作用。方法对照组患者治疗方法均选用5-氟脲嘧啶常规剂型腹腔内注射,每平方米500mg,治疗组的患者治疗选用5-氟脲嘧啶缓释粒子腹腔注射,每平方米500mg,两组一月一次,至少三次以上,当时评价毒副反应,停药一个月后评价疗效。结果使用5-FU缓释粒子治疗恶性腹腔积液疗效好于5-FU常规剂型,且副作用低,患者可耐受。
Objective To investigate the efficacy and side effects of 5-FU sustained-release particles in the treatment of malignant ascites. Methods Patients in the control group were treated with intraperitoneal injection of 5-fluorouracil routine intraperitoneal injection at a dose of 500 mg/m2. Patients in the treatment group were treated with 5-fluorouracil sustained-release particles intraperitoneally at a dose of 500 mg per square meter. Once, at least three or more times, the toxic side effects were evaluated at that time and the efficacy was evaluated one month after discontinuation. Results The efficacy of 5-FU sustained-release particles in the treatment of malignant peritoneal effusion was better than that of 5-FU conventional dosage forms, and the side effects were low and patients could tolerate it.