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应用癌胚抗原、花生凝集素、刀豆凝集素对12例单纯慢性萎缩胃炎、12例腺上皮中度异型增生病变、23例重度异型增生伴癌变、30例浸润进展型胃癌组织,做了检测,观察其阳性染色强度及分布模式异常。结果表明,3种标记物的阳性强度、分布模式异常均随着细胞异型增生程度的增高而增高,并有显著差异。发展至浸润进展型癌,CEA的强阳性率达80.0％,胞浆内分布达72.4％,ConA的强阳性率为83.3％,胞浆内分布85.7％,PNA的强阳性率为53.3％,胞浆内分布达64.3％。并发现癌巢旁间质中亦有PNA阳性反应,提示与肿瘤浸润扩散有关,为此这3种标志物可用于决定癌变的一种常规辅助病理诊断手段,提高对早期癌变的诊断率。
Carcinoembryonic antigen, peanut agglutinin, and aconite agglutinin were used to detect 12 cases of chronic atrophic gastritis, 12 cases of moderately middle-grade dysplasia, 23 cases of severe dysplasia and 30 cases of invasive advanced gastric cancer. Observe the abnormal staining intensity and distribution pattern. The results showed that the positive intensity and distribution pattern of the three markers all increased with the increase of cell dysplasia, and there were significant differences. Progressing to invasive advanced cancer, the strong positive rate of CEA was 80.0%, the intracytoplasmic distribution was 72.4%, the strong positive rate of ConA was 83.3%, the cytoplasmic distribution was 85.7%, and the strong positive rate of PNA was 53.3%. The distribution within the slurry reached 64.3%. It was also found that the PNA positive reaction was also found in the parasagittal interstitial tissue, suggesting that it was associated with tumor invasion and proliferation. For these reasons, these three markers could be used as a routine auxiliary pathological diagnosis method to determine canceration and improve the diagnostic rate of early canceration.