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目的观察百令胶囊联合缬沙坦治疗慢性移植肾肾病(CAN)的疗效及作用机制。方法 41例CAN患者随机分为对照组(19例)和试验组(22例),均给予三联免疫抑制疗法,试验组加用百令胶囊(每次2.0 g,每日3次)和缬沙坦(80~160 mg·d-1),治疗1年。检测治疗前后血压、血清肌酐(Scr)、24 h尿蛋白、血转化生长因子βl(TGF-βl)水平。结果治疗后,2组血压均较治疗前降低(P<0.05);试验组Scr、24 h尿蛋白及血TGF-βl水平较治疗前降低(P<0.05),且低于对照组治疗后水平(P<0.05)。结论百令胶囊联合缬沙坦治疗可改善肾功能,延缓CAN进展。
Objective To observe the curative effect and mechanism of Bailing capsule combined with valsartan on chronic allograft nephropathy (CAN). Methods 41 patients with CAN were randomly divided into control group (n = 19) and experimental group (n = 22). All patients were given triple immunosuppressive therapy. The patients in trial group were treated with Bailing capsule (2.0 g, 3 times daily) Tan (80 ~ 160 mg · d-1) for 1 year. Blood pressure, serum creatinine (Scr), 24 h urine protein and TGF-β1 were measured before and after treatment. Results After treatment, the blood pressure in both groups decreased significantly (P <0.05). The levels of Scr, 24 h urine protein and TGF-β1 in the experimental group were lower than those before treatment (P <0.05), and were lower than those in the control group (P <0.05). Conclusion Bailing capsule combined with valsartan can improve renal function and delay the progression of CAN.