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目的 评价国产卡维地洛的降压效应与安全性。方法 90例原发性高血压患者随机分为观察组与对照组 ,分别口服国产卡维地洛 1片 (10mg)或美多心安 1片 (2 5mg) ,2次 /d ,4周为 1疗程。 结果 卡维地洛组服药 4周后收缩压 (SBP)及舒张压 (DBP)与治疗前比较分别下降 (18.92± 11.5 8)、(12 .34± 7.2 5 )mmHg(P <0 .0 1) ,美多心安组与治疗前比较分别下降 (19.13± 9.70 )、(13.5 0± 7.4 6 )mmHg(P <0 .0 1) ;观察组与对照组总有效率分别为 89.4 8%与 80 .4 3% ,两组比较无显著差异 (P >0 .0 5 )。两药的不良反应均轻微 ,发生率分别为 2 .7%和 4 .4 %。结论 卡维地洛是一种安全有效的抗高血压药物
Objective To evaluate the antihypertensive effect and safety of domestic carvedilol. Methods Ninety patients with essential hypertension were randomly divided into two groups: observation group and control group. The patients were treated with domestic carvedilol (10 mg) or metoprolol (25 mg) twice a day for 4 weeks Course of treatment. Results The SBP and DBP in carvedilol group decreased (18.92 ± 11.58) and (12.34 ± 7.25) mmHg (P <0.01) after treatment for 4 weeks (19.13 ± 9.70) and (13.5 ± 7.46) mmHg respectively (P <0.01). The total effective rates in the observation group and the control group were 89.48% and 80 .4 3%, no significant difference between the two groups (P> 0.05). Adverse reactions to both drugs were mild, the incidence rates were 2.7% and 4.4%. Conclusion Carvedilol is a safe and effective anti-hypertensive drug