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目的 探讨乙型肝炎表面抗原阳性(HBsAg+)母亲的婴儿乙肝疫苗注入后早期免疫反应的特点。方法 依据母亲HBsAg的测定,将婴儿分为实验组与对照组,两组均于生后进行乙肝疫苗注射(10μg,0、1、6个月),每次疫苗注入前及3个月时都采血测定抗-HBs、IgG、IgM、CD3+、CD4+、CD8+、CD7+及CD21。结果 疫苗注入前所查各项指标及疫苗注入后各时间点的IgG、IgM和抗-HBs两组均无显著性差异;1个月和3个月时实验组的CD3+都明显低于对照组(P<0.05);3个月时实验组的CD4+和CD8+明显低于对照组(P<0.05);6个月时实验组的CD7+和CD21明显高于对照组(P<0.01)。结论 HBsAg(+)母亲的婴儿与健康母亲的婴儿相比,乙肝疫苗注入后机体的免疫反应存在差异,且主要反映在细胞免疫方面。
Objective To investigate the characteristics of early immune response after infusing hepatitis B vaccine into infants with hepatitis B surface antigen (HBsAg +) mothers. Methods According to the determination of maternal HBsAg, the infants were divided into experimental group and control group. Both groups were given hepatitis B vaccine after injection (10μg, 0, 1, 6 months) before and 3 months after each vaccination Blood samples were tested for anti-HBs, IgG, IgM, CD3 +, CD4 +, CD8 +, CD7 + and CD21. Results There was no significant difference between the indexes examined before vaccine injection and the IgG, IgM and anti-HBs at each time point after the vaccine injection. The CD3 + concentrations in the experimental group at 1 month and 3 months were significantly lower than those in the control group (P <0.05). At 3 months, the levels of CD4 + and CD8 + in the experimental group were significantly lower than those in the control group (P <0.05). At 6 months, the levels of CD7 + and CD21 in the experimental group were significantly higher than those in the control group (P <0.01). CONCLUSION: Compared with infants from healthy mothers, infants with HBsAg (+) mothers have different immune responses after hepatitis B vaccine injection, and are mainly reflected in cellular immunity.