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无论原发性或继发性肝癌预后均差。仅少数病人适于手术治疗,5年生存率在25～60%不等、现已肯定细胞具有热敏感性,42～45℃1小时可因蛋白质凝固引起细胞死亡。热疗对肿瘤的作用是综合性而且复杂的,加温可能造成肿瘤周围血流改向;肿瘤内血管收缩、pH 降低、低血糖、毛细血管通透性增加和水肿。尚观察到肿瘤而非个别肿瘤细胞较正常组织对热更为敏感。超过50℃这种差异即消失。较理想的方法是肿瘤区能达到所需的温度而对周围组织损伤轻微,高温疗法是诱使肿瘤发生坏死的简便易行的方法。现有人用50～80W 的高功率激光至肝表面以造成热坏死。其缺点是激光反射离开肝表面;深达肝脏需要暴露的表面无需如此高的功率,而且难以控制其穿透的深度和效应。间隙疗法即把治疗的释放点置在欲治疗区内。这是一种侵入性,但允许所采用的治疗更为准确的至所需要区域,而对周周组织影响较小。然而。
The prognosis of primary or secondary liver cancer is poor. Only a handful of patients are suitable for surgical treatment. The 5-year survival rate varies from 25 to 60%. It has been confirmed that the cells are heat-sensitive. 42-45°C for 1 hour can cause cell death due to protein coagulation. The effect of hyperthermia on the tumor is complex and complex. Warming may cause redirection of the blood flow around the tumor; intratumoral vasoconstriction, decreased pH, hypoglycemia, increased capillary permeability, and edema. It has been observed that tumors rather than individual tumor cells are more sensitive to heat than normal tissues. This difference disappears when it exceeds 50°C. The ideal method is to achieve the desired temperature in the tumor area and slight damage to the surrounding tissue. Hyperthermia therapy is a simple and easy method to induce tumor necrosis. Existing people use a high power laser of 50-80 W to the surface of the liver to cause thermal necrosis. The disadvantage is that the laser reflects off the surface of the liver; the surface deep enough to reach the liver does not require such high power, and it is difficult to control the depth and effect of its penetration. Gap therapy places the release point of treatment in the area to be treated. This is invasive, but allows the treatment to be applied more accurately to the desired area, with less impact on the week-week organization. however.