目的:观察吗啡类药物应用的不良反应,以提高临床用药的安全性。方法:通过观察接受吗啡类药物治疗的晚期重度癌痛患者,记录治疗中出现的不良反应。结果:不良反应中以便秘的发生率最高,占63%,恶心呕吐35%,嗜睡、过度镇静5%,眩晕7%,排尿困难3%,精神错乱和神经系统反应3%,瘙痒1%,呼吸抑制0.15%,无成瘾性。结论:对癌痛患者合理应用吗啡类药物是比较安全的。 Objective: To observe the adverse reactions of morphine drugs in order to improve the safety of clinical medication. METHODS: Adverse reactions to treatment were recorded by observing patients with advanced severe cancer who received morphine. Results: The incidence of constipation was the highest in adverse reactions, accounting for 63%, nausea and vomiting 35%, drowsiness, excessive sedation 5%, dizziness 7%, dysuria 3%, insanity and nervous system reactions 3%, pruritus 1% Respiratory depression 0.15%, no addiction. Conclusion: The rational use of morphine in patients with cancer pain is relatively safe.