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目的观察银杏注射液对儿童原发性肾病综合征(PNS)的疗效。方法46例PNS患儿随机分成观察组26例,对照组20例,观察组在常规激素治疗的基础上加用银杏注射液治疗,对照组以常规激素治疗,其它治疗2组相同。分别测定2组治疗前后的血液流变学的变化、24h尿蛋白、血清白蛋白(ALB)、血2-微球蛋白(2-MG)、尿素氮(BUN)、血肌酐(SCr)、平均动脉血压(MAP)及总胆固醇(TC)、三酰甘油(TG)、免疫球蛋白IgA、IgG、IgM、补体C3等指标。结果观察组与对照组相比能使血黏度改善(P<0.05);24h尿蛋白、BUN、血2-MG、TC、MAP等明显降低(P<0.05);尿蛋白转阴时间明显缩短(P<0.05),IgA、IgG、C3水平明显升高(P<0.05)。结论银杏注射液具有降低血液黏滞度,改善微循环,降低血压,减少尿白蛋白,缩短尿蛋白转阴时间,保护肾功能等作用,对儿童PNS有治疗作用。
Objective To observe the effect of Ginkgo biloba injection on children with primary nephrotic syndrome (PNS). Methods 46 children with PNS were randomly divided into observation group (n = 26) and control group (n = 20). The observation group was treated with ginkgo injection on the basis of conventional hormone therapy. The control group was treated with conventional hormone. The other two groups were the same. The changes of hemorheology before and after treatment were measured respectively. The 24h urine protein, serum albumin (ALB), blood 2-microglobulin (2-MG), blood urea nitrogen (BUN), serum creatinine (SCr) Arterial blood pressure (MAP) and total cholesterol (TC), triglyceride (TG), immunoglobulin IgA, IgG, IgM, complement C3 and other indicators. Results Compared with the control group, the blood viscosity could be improved in the observation group (P <0.05), while the levels of urinary protein, BUN, blood 2-MG, TC and MAP were significantly decreased P <0.05), IgA, IgG, C3 levels were significantly increased (P <0.05). Conclusion Ginkgo biloba injection has the effect of reducing blood viscosity, improving microcirculation, lowering blood pressure, reducing urinary albumin, shortening urinary protein to negative time, and protecting renal function, and has a therapeutic effect on PNS in children.