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在碱性介质中,环吡酮胺对H2O2氧化鲁米诺化学发光体系有较强的增敏作用,据此建立了流动注射-化学发光测定环吡酮胺的新方法,显著地提高了检测灵敏度。在优化的试验条件下,发光信号的增敏值(ΔI)与环吡酮胺溶液的浓度ρ在0.25～4.0μg/mL范围内线性关系良好,检出限为0.06μg/mL。对浓度为1μg/mL环吡酮胺进行11次平行测定,相对标准偏差(RSD)为1.9%。方法可直接进样分析,分析频率为100/h。该方法已用于环吡酮胺制剂溶出度的研究。
In alkaline medium, ciclopirox olamine H2O2 oxidation of luminol chemiluminescence system has a strong sensitization, thus establishing a flow injection - chemiluminescence determination of ciclopirox a new method was significantly improved detection Sensitivity. Under the optimized experimental conditions, the sensitization value (ΔI) of luminescent signal and the concentration of ciclopirox olamine in the range of 0.25 ~ 4.0μg / mL showed a good linearity with a detection limit of 0.06μg / mL. Eleven replicates of ciclopirox olamine at a concentration of 1 μg / mL showed a relative standard deviation (RSD) of 1.9%. Methods can be directly injected into the analysis, the analysis of the frequency of 100 / h. This method has been used to study the dissolution of ciclopirox olamine preparations.