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目的探讨淋巴结转移数目对行手术治疗的结肠癌患者预后的影响。方法回顾性分析2005年1月2007年12月符合筛选标准的148例行手术治疗的结肠癌患者的临床和随访资料,按照淋巴结转移数目进行分组:N0组(0枚)91例、N1组(1～3枚)41例、N2组(≥4枚)16例,采用Kaplan-Meier法进行生存分析,用Log-rank比较3组术后3年生存率,等级资料采用秩和检验,用χ2检验进行两两比较术后3年局部复发率、远处转移率和死亡率情况。结果 N0、N1、N2 3组的术后3年生存率分别为88.1%、71.4%、61.1%,3组生存率差异有统计学意义(P=0.003);N0、N1、N2 3组的总体局部复发率、远处转移率和死亡率的差异有统计学意义(P=0.006,0.001,0.005)。结论淋巴结转移数目是结肠癌患者术后3年生存情况的危险因素,无淋巴结转移的患者术后3年生存情况明显比有淋巴结转移者好。
Objective To investigate the effect of the number of lymph node metastases on the prognosis of patients with colon cancer undergoing surgical treatment. Methods The clinical and follow-up data of 148 patients with colorectal cancer who met the screening criteria in January 2005 and December 2007 were retrospectively analyzed. According to the number of lymph node metastasis, 91 patients were in group N0 (n = 0), N1 41 cases, N2 group (≥4 pieces), 16 cases were analyzed by Kaplan-Meier method. Log-rank was used to compare the 3-year survival rate of three groups. Rank data were analyzed by rank sum test andχ2 Test to compare the two sides after 3 years of local recurrence rate, distant metastasis rate and mortality. Results The 3-year survival rates of the N0, N1 and N2 3 groups were 88.1%, 71.4% and 61.1%, respectively. There was significant difference in the survival rates between the three groups (P = 0.003) The difference of local recurrence rate, distant metastasis rate and mortality was statistically significant (P = 0.006,0.001,0.005). Conclusions The number of lymph node metastasis is the risk factor for the 3-year survival of patients with colon cancer. The 3-year survival rate of patients without lymph node metastasis is significantly better than that of patients with lymph node metastasis.