论文部分内容阅读
采用葡萄球菌肠毒素B(SEB)分次静脉注射,牛血清白蛋白(BSA)隔日灌胃及弗氏佐剂分次注射,建立SD大鼠系膜增殖型肾小球肾炎模型。结果显示:自实验的第6周末大鼠肾小球出现系膜细胞及系膜基质增生,至第8周末呈现明显的系膜细胞及系膜基质增生。本模型制作时间较短(6～8周),病变稳定。模型的建立进一步证实胃肠粘膜免疫在系膜增殖型肾小球肾炎发病中起着重要的作用。
The mesangial proliferative glomerulonephritis model of SD rats was established by intravenous injection of staphylococcal enterotoxin B (SEB), intragastric administration of bovine serum albumin (BSA) every other day and Freund’s adjuvant. The results showed that mesangial cells and mesangial matrix hyperplasia occurred in the glomerulus of rats at the 6th week after the experiment, and obvious mesangial cells and mesangial matrix hyperplasia appeared at the end of the 8th week. The model is shorter production time (6 to 8 weeks), stable disease. The establishment of the model further confirmed that gastrointestinal mucosal immunity plays an important role in the pathogenesis of mesangial proliferative glomerulonephritis.