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目的:探讨白细胞介素-10(IL-10)在慢性阻塞性肺疾病(COPD)气道炎症及免疫调节中的作用。方法:采用酶联免疫吸附法(ELISA)检测10例COPD急性加重期患者(COPD组)和10例健康成年人(成常对照组)痰及血清的IL-10水平。结果:COPD组痰IL-10水平为(37.40±5.25)ng/L,显著高于正常对照(28.30±7.75)ng/L(P<0.01)。此外,COPD患者痰IL-10水平亦明显高于其血清水平(P<0.01),且痰IL-10水平与其血清水平无相关关系(P>0.05)。结论:IL-10参与了COPD气道炎症过程,可能在免疫调节方面起重要作用,检测痰IL-10水平较血清更能直接反映COPD气道炎症的免疫调节状况。
Objective: To investigate the role of interleukin-10 (IL-10) in airway inflammation and immune regulation in patients with chronic obstructive pulmonary disease (COPD). Methods: The levels of IL-10 in sputum and serum of 10 patients with COPD exacerbation (COPD group) and 10 healthy adults (control group) were detected by enzyme-linked immunosorbent assay (ELISA). Results: The sputum IL-10 level in COPD group was (37.40 ± 5.25) ng / L, which was significantly higher than that in control group (28.30 ± 7.75) ng / L (P <0.01). In addition, sputum IL-10 level in patients with COPD was also significantly higher than its serum level (P <0.01), and sputum IL-10 levels and serum levels had no correlation (P> 0.05). CONCLUSION: IL-10 participates in airway inflammation in COPD and may play an important role in immune regulation. IL-10 level in sputum may reflect the immunoregulatory status of airway inflammation in COPD more directly than serum.