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20例无消化性溃疡史、头颅创伤昏迷的患者,随机分为每天给予静注甲氰脒胺1克的治疗组和给安慰剂的对照组各10例。两组年龄和性别均相似。所有患者均接受相同的标准治疗,不给有害于胃的药物。入院时胃镜检查,两组均为9例胃正常,1例胃糜烂;第3天作第二次镜检显示治疗组2例胃糜烂,对照组5例胃损害(1例溃疡、2例糜烂、2例急性出血性胃炎);第6天作第三次镜检,治疗组10例均正常,对照组7例有胃损害(2例溃疡、5例糜烂)。可是甲氰脒胺对胃损害的形成具有明显的保护性作用。
Twenty patients without history of peptic ulcer and head trauma coma were randomly divided into treatment group (n = 10) and control group (n = 10). Both groups were similar in age and gender. All patients underwent the same standard of care and did not give any drugs that were harmful to the stomach. At the time of admission, endoscopy was performed in both groups, with 9 cases of normal stomach and 1 case of gastric erosion. On the third day, the second microscopic examination showed that gastric erosion was found in 2 cases in the treatment group and 5 cases in the control group (1 case of ulcer and 2 cases of erosion , 2 cases of acute hemorrhagic gastritis); on the 6th day for the third microscopic examination, 10 cases in the treatment group were normal, and 7 cases in the control group had stomach damage (2 cases of ulcer and 5 cases of erosion). However, cetamidine amine formation of gastric damage has a significant protective effect.