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目的分析瞬时弹性成像(fibroscan)对慢性乙肝患者肝脏硬度测量值与血清纤维化指标、肝功能、血常规、HBV状态及肝脏影像学检查之间的相关性。方法对68例慢性乙肝患者使用Fibroscan测量肝脏硬度,并同时检测血清纤维化指标(HA、LN、IV-col、PIIIP)血常规、肝功能(ALT、AST、GGT、TBIL及A/G)以及行影像学检查,分析弹性测量值与肝纤指标、转氨酶以及B超或CT结果之间以上指标的相关性。结果弹性测量值与HA、LN、IV-col、AST、GGT呈正相关(r分别为0.662,0.558,0.562,0.695,0.686)。Fibroscan值在HBeAg阳性及阴性组之间无明显差异(P=0.583)。在31例影像学正常组患者中,肝脏硬度测量值为7.895±4.007,21例光点增粗中硬度测量值为10.357±4.602,16例肝硬化组为18.342±4.347,正常组与光点增粗组之间比较差异有统计学意义(P=0.038),正常组与肝硬化组比较差异有统计学意义(P=0.00),但光点增粗组与肝硬化组之间差异无统计学意义(P=0.066)。结论Fibroscan测量值与肝功能损伤的程度及血清肝纤维化指标明显相关。
OBJECTIVE: To analyze the correlation between transient fibrosis measurements of liver cirrhosis and serum fibrosis markers, liver function, blood tests, HBV status and liver imaging in chronic hepatitis B patients. Methods Sixty-eight patients with chronic hepatitis B were enrolled in this study. The liver stiffness (ALT, AST, GGT, TBIL and A / G) and serum fibrosis indexes (HA, LN, IV-col and PIIIP) Line imaging examination, analysis of elastic measurements and liver fiber index, transaminase and B ultrasound or CT results between the above indicators. The results of elastic measurement and HA, LN, IV-col, AST, GGT was positively correlated (r were 0.662,0.558,0.562,0.695,0.686). There was no significant difference in Fibroscan values between HBeAg positive and negative groups (P = 0.583). In 31 patients with normal imaging group, the measured value of the liver hardness was 7.895 ± 4.007, the measured value of the hardness of the 21 spots was 10.357 ± 4.602, and that of the 16 patients with cirrhosis was 18.342 ± 4.347. There was significant difference between the crude groups (P = 0.038), there was significant difference between the normal group and the cirrhosis group (P = 0.00), but there was no significant difference between the thick spots group and the cirrhosis group Significance (P = 0.066). Conclusions Fibroscan measurements are significantly related to the degree of liver injury and serum markers of liver fibrosis.