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目的:探讨高孕激素状态下促排卵对卵巢低反应患者LH水平的影响及促排卵效果。方法:将100例存在卵巢低反应的患者随机分为观察组、对照组,每组各50例。观察组采用醋酸甲羟孕酮联合注射用尿促性素促排卵,对照组采用超短方案。分析观察组促排卵过程中LH水平的变化,比较两组患者的获卵数、成熟卵数、优质胚胎数及行冻融胚胎移植(FET)后的妊娠率等。结果:观察组在促排卵过程中未监测到LH峰;两组的获卵数、成熟卵数、受精数等比较,差异均无统计学意义(P>0.05),两组行FET后的妊娠率、胚胎种植率比较,差异无统计学意义(P>0.05)。结论:高孕激素状态下促排卵能有效抑制LH峰,对于卵巢低反应者能达到较好的促排卵效果,可作为一种备选方法。
OBJECTIVE: To investigate the effect of ovulation induced by high progesterone on the LH level in patients with low ovarian response and ovulation induction. Methods: 100 cases of ovarian low response patients were randomly divided into observation group, control group, 50 cases in each group. Observation group using medroxyprogesterone acetate injection combined with urinary gonadotropin ovulation, the control group with ultra-short program. The change of LH level during ovulation induction in the observation group was analyzed. The number of oocytes, the number of mature eggs, the number of high quality embryos and the pregnancy rate after freezing and thawing embryo transfer (FET) were compared between the two groups. Results: The LH peak was not observed during the ovulation induction in the observation group. There was no significant difference in the numbers of oocytes, mature oocytes and fertilization between the two groups (P> 0.05) Rate, embryo implantation rate, the difference was not statistically significant (P> 0.05). CONCLUSION: Ovulation with high progesterone can effectively inhibit the LH peak, which can be used as an alternative method for ovulation-poor ovarian response.