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目的：探讨在常规连续放疗中，总治疗时间延长及疗程中断长短对鼻咽癌局部控制和远期生存的影响。方法：选择 1989年 1月～ 1992年 12月在我科住院接受单纯常规连续放疗、经病理证实的Ⅰ～Ⅳ a期鼻咽癌病人 196例进行回顾性分析，以中位总疗程时间及疗程中断时间为界分别分为疗程≤ 50天和 >50天两组及疗程中断≤ 5天和 >5天两组，采用 Kaplan Meier和 Log rank法对局控、无瘤生存和无远处转移率进行分组比较，时间因素与局控率关系采用线性回归分析，多因素分析采用 Cox模型法。结果：在未限定总剂量范围之前，不同疗程组或疗程中断组之间的 5年局控率无显著差异。当选择鼻咽剂量在 66～ 70 Gy范围的 115例病人进行分析时，疗程 >50天和中断 >5天组的 5年局控率（分别为 44.0％和 38.9％）、无瘤生存率（ 39.8％和 33.5％）和无远处转移率（ 48.5％和 42.6％）均明显低于疗程≤ 50天和中断≤ 5天组（相应为 63.4％和 63.1％、 63.5％和 63.2％、 68.7％和 68.9％）， P
OBJECTIVE: To investigate the effects of prolonged treatment and duration of treatment on the local control and long-term survival of NPC in routine continuous radiotherapy. Methods: A retrospective analysis was performed on 196 patients with pathologically confirmed stage Ⅰ ~ Ⅳ a nasopharyngeal carcinoma who underwent routine radiotherapy from January 1989 to December 1992 in our hospital. The median duration of treatment and the duration of treatment Intermittent time as the community were divided into treatment ≤ 50 days and> 50 days two groups and treatment interruptions ≤ 5 days and> 5 days in both groups, using Kaplan Meier and Log rank on the control, tumor-free survival and no distant metastasis For group comparison, the relationship between time factor and control rate was analyzed by linear regression analysis, and Cox model method was used for multivariate analysis. Results: There was no significant difference in 5-year local control rates between treatment groups or treatment discontinuation groups before the total dose range was defined. When 115 patients with a nasopharyngeal dose of 66-70 Gy were enrolled for analysis, the 5-year site-control rates (44.0% and 38.9%, respectively) for treatment> 50 days and discontinuation> 5 days, and tumor-free survival 39.8% and 33.5%, respectively) and distant metastases (48.5% and 42.6%) were significantly lower than those treated less than 50 days and less than 5 days (63.4% and 63.1%, 63.5% and 63.2%, 68.7% And 68.9%), P.