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目的探讨合并精神症状的脑膜瘤患者的治疗方法。方法回顾性分析16例合并精神症状脑膜瘤患者的临床资料,采用阳性与阴性症状量表(PANSS)评分评定手术前、手术后、术后6个月和术后12个月患者的精神症状,以及应用临床疗效总评定量表评定疗效。结果 16例患者的治疗有效率为100%。术后患者PANSS中P3、P7及总分低于术前(P<0.05或<0.01)。术后6个月,PANSS中P1、P3、P4、P7、N7及总分低于术后(P<0.05或<0.01)。术后12个月,PANSS总分低于术后6个月(P<0.01)。结论合并精神症状的脑膜瘤患者的术前、术后抗精神病治疗,尤其是术后6个月的抗精神病维持治疗,对患者的生活质量提高十分重要。
Objective To investigate the treatment of meningiomas with psychiatric symptoms. Methods The clinical data of 16 patients with meningioma with psychiatric symptoms were retrospectively analyzed. The positive and negative symptom scales (PANSS) were used to assess the mental symptoms of patients with meningioma before surgery, after surgery, 6 months and 12 months after operation. As well as the application of clinical efficacy rating scale to assess the efficacy. Results The treatment efficiency of 16 patients was 100%. Postoperative patients with PANSS P3, P7 and total score lower than preoperative (P <0.05 or <0.01). At 6 months after operation, the PANSS P1, P3, P4, P7, N7 and total score were lower than those after operation (P <0.05 or <0.01). At 12 months after surgery, the PANSS score was lower than 6 months after surgery (P <0.01). Conclusions Preoperative and postoperative antipsychotics in patients with meningioma with psychiatric symptoms, especially antipsychotic maintenance treatment after 6 months, are very important for improving the quality of life of patients.