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目的:检测Cosmc、T抗原和VEGFR/KDR在婴儿血管瘤不同分期中表达的变化,探讨其在婴儿血管瘤病程发展演化中的意义。方法:采用免疫组织化学法检测Cosmc和T抗原和VEGFR/KDR在45例手术切除的婴儿血管瘤与10例正常皮肤组织的表达情况。所有标本经术后病理报告证实为婴儿血管瘤,根据Mulliken标准分为增生组、消退组和消退完成组。结果:1Cosmc、T抗原和VEGFR/KDR在增生组中高表达,阳性表达率明显高于消退组,统计结果具有显著性差异(P<0.05),且增生组与消退组的表达分别与对照组比较具有显著性差异(P<0.05)。2Cosmc在婴儿血管瘤中的表达与T抗原的表达呈显著正相关(r=0.50,P<0.01)。3VEGFR/KDR在婴儿血管瘤中的表达与T抗原的表达呈显著正相关(r=0.53,P<0.01)。结论:Cosmc、T抗原和VEGFR/KDR可能在婴儿血管瘤增生、消退过程中起关键作用。
OBJECTIVE: To detect the changes of Cosmc, T antigen and VEGFR / KDR in different stages of infantile hemangiomas and to explore its significance in the development and progression of infantile hemangiomas. Methods: Immunohistochemistry was used to detect the expression of Cosmc and T antigen and VEGFR / KDR in 45 cases of surgical resected infantile hemangiomas and 10 cases of normal skin tissues. All the specimens were confirmed as infantile hemangiomas by postoperative pathology report. According to Mulliken criteria, they were divided into hyperplasia group, extinction group and subsided group. Results: The expression of 1Cosmc, T antigen and VEGFR / KDR were highly expressed in the proliferative group, the positive expression rate was significantly higher than that in the regression group (P <0.05). The expression of ICOSmc, T antigen and VEGFR / There was significant difference (P <0.05). The expression of 2Cosmc in infantile hemangiomas was positively correlated with the expression of T antigen (r = 0.50, P <0.01). The expression of 3VEGFR / KDR in infantile hemangiomas was positively correlated with the expression of T antigen (r = 0.53, P <0.01). Conclusion: Cosmc, T antigen and VEGFR / KDR may play a key role in the proliferation and regression of infantile hemangiomas.