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目的研究ApoB基因VNTR多态性与行为生活方式在浙江省武义县农村人群长寿发生中的交互作用。方法抽样调查并体检农村长寿及对照人群346人,应用聚合酶链反应技术检测其ApoB基因3’VNTR多态性,运用叉生分析研究行为生活方式与基因的交互作用。结果经常吃肉类食品、现吸烟是长寿的危险因素(OR=0.448和0.391,P<0.05);经常吃新鲜蔬菜、经常吃豆制品是长寿的促进因素(OR=2.523和3.444,P<0.05)。ApoB基因的VNTR多态性表现为VNTR的大等位基因不利于长寿(OR=0.208,P<0.05)。经常吃肉食及现吸烟与VNTR基因存在明显的协同交互作用(OR=4.016和4.362,P<0.05)。结论 ApoB基因VNTR多态性与行为生活方式在浙江省武义县农村人群长寿发生中存在交互作用。
Objective To study the interaction between VNTR polymorphism of ApoB gene and behavioral lifestyle in the longevity of rural population in Wuyi County, Zhejiang Province. Methods A total of 346 people with long-lived and control subjects in rural areas were sampled and examined. Polymerase chain reaction (PCR) was used to detect the 3’VNTR polymorphism of ApoB gene. Cross-species analysis was used to study the interaction between behavioral lifestyle and genes. The results of regular eating meat, smoking is a risk factor for longevity (OR = 0.448 and 0.391, P <0.05); often eat fresh vegetables, often eat soy products are the promoting factors of longevity (OR = 2.523 and 3.444, P <0.05 ). The VNTR polymorphism of ApoB gene showed that the large allele of VNTR is not conducive to longevity (OR = 0.208, P <0.05). There was a significant synergistic interaction between VNTR and regular consumption of carnitine and smoking (OR = 4.016 and 4.362, P <0.05). Conclusion The VNTR polymorphism of ApoB gene interacts with behavioral lifestyle in the longevity of rural population in Wuyi County, Zhejiang Province.