醛固酮是体内钠平衡的重要调节激素,它通过激活盐皮质激素受体(mineralocorticoid receptor,MR)而产生作用,但其中的机制尚未完全明确。方法 :应用体外和体内实验,研究血管组织中MR激活对纹蛋白(striatin)水平的影响。结果 :在小鼠心脏和主动脉中,饮食钠的限制与纹蛋白水平增加相关;纹蛋白和 Aldosterone is an important regulator of sodium balance in the body. It acts by activating the mineralocorticoid receptor (MR), but the mechanism is not completely understood. Methods: In vitro and in vivo experiments were performed to investigate the effect of MR activation on the striatin level in vascular tissue. RESULTS: In mice hearts and aorta, dietary sodium limitation was associated with an increase in the levels of the stria proteins;